ATF4 protects against neuronal death in cellular Parkinson's disease models by maintaining levels of parkin.

@article{Sun2013ATF4PA,
  title={ATF4 protects against neuronal death in cellular Parkinson's disease models by maintaining levels of parkin.},
  author={Xiaotian Sun and Jin Liu and John Fonda Crary and Cristina Malagelada and David Sulzer and Lloyd A Greene and Oren A. Levy},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 6},
  pages={2398-407}
}
Parkinson's disease (PD) is a common neurodegenerative disorder, for which there are no effective disease-modifying therapies. The transcription factor ATF4 (activating transcription factor 4) is induced by multiple PD-relevant stressors, such as endoplasmic reticulum stress and oxidative damage. ATF4 may exert either protective or deleterious effects on cell survival, depending on the paradigm. However, the role of ATF4 in the pathogenesis of PD has not been explored. We find that ATF4 levels… CONTINUE READING

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