ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis.

  title={ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis.},
  author={Souvik Dey and Carly M. Sayers and Ioannis I Verginadis and Stacey Lynne Lehman and Yi Cheng and George J. Cerniglia and Stephen W. Tuttle and Michael D. Feldman and Paul J Zhang and Serge Yu. Fuchs and J Alan Diehl and Constantinos Koumenis},
  journal={The Journal of clinical investigation},
  volume={125 7},
The integrated stress response (ISR) is a critical mediator of cancer cell survival, and targeting the ISR inhibits tumor progression. Here, we have shown that activating transcription factor 4 (ATF4), a master transcriptional effector of the ISR, protects transformed cells against anoikis - a specialized form of apoptosis - following matrix detachment and also contributes to tumor metastatic properties. Upon loss of attachment, ATF4 activated a coordinated program of cytoprotective autophagy… CONTINUE READING
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