ATF4 Gene Network Mediates Cellular Response to the Anticancer PAD Inhibitor YW3-56 in Triple-Negative Breast Cancer Cells.

@article{Wang2015ATF4GN,
  title={ATF4 Gene Network Mediates Cellular Response to the Anticancer PAD Inhibitor YW3-56 in Triple-Negative Breast Cancer Cells.},
  author={Shu De Wang and Xiangyun Amy Chen and Jing Hu and Jian-kang Jiang and Yunfei Li and Ka Yim Chan-Salis and Ying Gu and Gong Chen and Craig Thomas and B. Franklin Pugh and Yanming Wang},
  journal={Molecular cancer therapeutics},
  year={2015},
  volume={14 4},
  pages={877-88}
}
We previously reported that a pan-PAD inhibitor, YW3-56, activates p53 target genes to inhibit cancer growth. However, the p53-independent anticancer activity and molecular mechanisms of YW3-56 remain largely elusive. Here, gene expression analyses found that ATF4 target genes involved in endoplasmic reticulum (ER) stress response were activated by YW3-56. Depletion of ATF4 greatly attenuated YW3-56-mediated activation of the mTORC1 regulatory genes SESN2 and DDIT4. Using the ChIP-exo method… CONTINUE READING

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