ATF3-mediated NRF2/HO-1 signaling regulates TLR4 innate immune responses in mouse liver ischemia/reperfusion injury.

@article{Rao2015ATF3mediatedNS,
  title={ATF3-mediated NRF2/HO-1 signaling regulates TLR4 innate immune responses in mouse liver ischemia/reperfusion injury.},
  author={Jianhua Rao and Xihong Qian and Guangyun Li and Xuebo Pan and Chenxi Zhang and Feng Zhang and Yuan Zheng Zhai and Xiao hong Wang and Li-na Lu},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2015},
  volume={15 1},
  pages={
          76-87
        }
}
Activating transcription factor 3 (ATF3) is a stress-induced transcription factor that has been shown to repress inflammatory gene expression in multiple cell types and diseases. However, little is known about the roles and mechanisms of ATF3 in liver ischemia/reperfusion injury (IRI). In warm and cold liver IRI models, we showed that ATF3 deficiency significantly increased ischemia/reperfusion (IR)-stressed liver injury, as evidenced by increased serum alanine aminotransferase levels… CONTINUE READING
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