ATF3 increases the intrinsic growth state of DRG neurons to enhance peripheral nerve regeneration.

@article{Seijffers2007ATF3IT,
  title={ATF3 increases the intrinsic growth state of DRG neurons to enhance peripheral nerve regeneration.},
  author={Rhona Seijffers and Charles D Mills and Clifford J Woolf},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2007},
  volume={27 30},
  pages={7911-20}
}
Peripheral axons of dorsal root ganglion (DRG) neurons, but not their central axons in the dorsal columns, regenerate after injury. However, if the neurons are conditioned by a peripheral nerve injury into an actively growing state, the rate of peripheral axonal growth is accelerated and the injured central axons begin to regenerate. The growth-promoting effects of conditioning injuries have two components, increased axonal growth and a reduced response to inhibitory myelin cues. We have… CONTINUE READING
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