ATF-2 controls transcription of Maspin and GADD45α genes independently from p53 to suppress mammary tumors

@article{Maekawa2008ATF2CT,
  title={ATF-2 controls transcription of Maspin and GADD45α genes independently from p53 to suppress mammary tumors},
  author={Takayo Maekawa and Yasuyo Sano and Toshie Shinagawa and Zia Rahman and Takahiko Sakuma and Shintaro Nomura and Jonathan D Licht and Shunsuke Ishii},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={1045-1054}
}
The activating transcription factor, ATF-2, is a target of p38 and JNK that are involved in stress-induced apoptosis. Heterozygous Atf-2 mutant (Atf-2+/−) mice are highly prone to mammary tumors. The apoptosis-regulated gene GADD45α and the breast cancer suppressor gene Maspin, both of which are known to be p53 target genes, are downregulated in the mammary tumors arisen in Atf-2+/− mice. Here, we have analysed how ATF-2 controls the transcription of GADD45α and Maspin. ATF-2 and p53… CONTINUE READING

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