Corpus ID: 42736295

ATAstructure as having a causal role in the mechanism of TATATAA ; Roog 20 5 CCTTGTTTCT TTTAGGCGTTAGsilencing

@inproceedings{Kamakaka1998ATAstructureAH,
  title={ATAstructure as having a causal role in the mechanism of TATATAA ; Roog 20 5 CCTTGTTTCT TTTAGGCGTTAGsilencing},
  author={R. Kamakaka and J. Rine},
  year={1998}
}
A promoter fusion library of Saccharomyces cerevisiae genes was used to exploit phenotypes associated with altered protein dosage. We identified a novel gene, SAS10, by the ability of Sas10p, when overproduced, to disrupt silencing. The predicted Sas10p was 70,200 kD and strikingly rich in charged amino acids. Sas10p was exclusively nuclear in all stages of the cell cycle. Overproduction of Sas10p caused derepression of mating type genes at both HML and HMR, as well as of URA3, TRP1, and ADE2… Expand

Figures and Tables from this paper

References

SHOWING 1-10 OF 10 REFERENCES
Chromatin Structure and EpigeSIR 2 and SIR 4 interactions differ in core and extended telomeric heterochromatin in yeast
  • Genes Dev .
  • 1995
Transcriptional silencing of Ty 1 elements in thealso been observed for other proteins involved in silencRDN 1 locus of yeast
  • 1997
Epigenetic switching of transcriptional states : cisand transacting factors affectingtance and strength , and by SIR 3 dosage
  • Genes Dev .
  • 1993
Position effect variegation and establishment of silencing at the HMR locus in Saccharomyces cerevisiae
  • Mol . Cell . Biol . BioEssays
  • 1992
A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA ininteracts with SIR 4 and regulates silencing in S . cerevisiae
  • Cell Genetics
SIR 3 and SIR 4 proteins are required for the positioning tional silencing in yeast ribosomal DNA
  • Genes Dev .