ATAC-see reveals the accessible genome by transposase-mediated imaging and sequencing

@article{Chen2016ATACseeRT,
  title={ATAC-see reveals the accessible genome by transposase-mediated imaging and sequencing},
  author={Xingqi Chen and Ying Shen and Will E. Draper and Jason D Buenrostro and Ulrike M. Litzenburger and Seung Woo Cho and Ansuman T Satpathy and Ava C. Carter and Rajarshi P. Ghosh and Alexandra East-Seletsky and Jennifer A. Doudna and William J Greenleaf and Jan T Liphardt and Howard Y Chang},
  journal={Nature Methods},
  year={2016},
  volume={13},
  pages={1013-1020}
}
Spatial organization of the genome plays a central role in gene expression, DNA replication, and repair. But current epigenomic approaches largely map DNA regulatory elements outside of the native context of the nucleus. Here we report assay of transposase-accessible chromatin with visualization (ATAC-see), a transposase-mediated imaging technology that employs direct imaging of the accessible genome in situ, cell sorting, and deep sequencing to reveal the identity of the imaged elements. ATAC… CONTINUE READING

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