AT1A-deficient mice show less severe progression of liver fibrosis induced by CCl(4).

@article{Kanno2003AT1AdeficientMS,
  title={AT1A-deficient mice show less severe progression of liver fibrosis induced by CCl(4).},
  author={Keishi Kanno and Susumu Tazuma and Kazuaki Chayama},
  journal={Biochemical and biophysical research communications},
  year={2003},
  volume={308 1},
  pages={177-83}
}
The renin-angiotensin system has been shown to contribute to fibrogenesis in varieties of organs, including the liver. Here, we investigated whether the angiotensin II type 1A receptor (AT1A) is implicated in the development of liver fibrosis, using AT1A-deficient and wild-type (WT) mice. After single dose of carbon tetrachloride (CCl(4)), there were no significant differences between two groups with regard to hepatic inflammation and necrosis. After 4 weeks of treatment with CCl(4… CONTINUE READING
38 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 38 extracted citations

Similar Papers

Loading similar papers…