AT1 receptors as mechanosensors.

@article{Schnitzler2011AT1RA,
  title={AT1 receptors as mechanosensors.},
  author={Michael Mederos y Schnitzler and Ursula Storch and Thomas Gudermann},
  journal={Current opinion in pharmacology},
  year={2011},
  volume={11 2},
  pages={112-6}
}
G-protein-coupled receptors are appreciated as central components of neurohormonal signaling. Recently, it turned out that they may also play a role in mechanotransduction. The angiotensin II AT(1) receptor was the first G-protein-coupled receptor claimed to be a mechanosensor. In the meantime, several other G(q/11)-coupled receptors were found to be sensitive to mechanical stimuli. Furthermore, there is first evidence to support the concept that G(i/o)-coupled receptors are susceptible to… CONTINUE READING

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