AT1 receptor signaling pathways in the cardiovascular system.

  title={AT1 receptor signaling pathways in the cardiovascular system.},
  author={T Kawai and Steven J. Forrester and Shannon O'Brien and Ariele Baggett and Victor Rizzo and Satoru Eguchi},
  journal={Pharmacological research},
  volume={125 Pt A},
The importance of the renin angiotensin aldosterone system in cardiovascular physiology and pathophysiology has been well described whereas the detailed molecular mechanisms remain elusive. The angiotensin II type 1 receptor (AT1 receptor) is one of the key players in the renin angiotensin aldosterone system. The AT1 receptor promotes various intracellular signaling pathways resulting in hypertension, endothelial dysfunction, vascular remodeling and end organ damage. Accumulating evidence shows… CONTINUE READING


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