AT1 receptor characteristics of angiotensin analogue binding in human synovium.

@article{Walsh1994AT1RC,
  title={AT1 receptor characteristics of angiotensin analogue binding in human synovium.},
  author={Denis Walsh and Tomoyuki Suzuki and Greg A Knock and David R. Blake and Julia M P Polak and John Wharton},
  journal={British journal of pharmacology},
  year={1994},
  volume={112 2},
  pages={435-42}
}
1. Angiotensin II (AII) reduces blood flow, modulates vascular remodelling and is a growth factor. Human inflammatory arthritides are characterized by synovial hypoperfusion, hypoxia and proliferation. We aimed to localize and characterize receptors for AII in human synovium. 2. We used quantitative in vitro receptor autoradiography with [125I]-(Sar1, Ile8)AII and [125I]-AII on human synovium from patients with chondromalacia patellae, osteoarthritis and rheumatoid arthritis. 3. [125I]-(Sar1… CONTINUE READING

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