AT1 receptor blockade delays postlactational mammary gland involution: a novel role for the renin angiotensin system.

@article{Nahmod2012AT1RB,
  title={AT1 receptor blockade delays postlactational mammary gland involution: a novel role for the renin angiotensin system.},
  author={Karen Amelia Nahmod and Thomas Walther and Nadia Cambados and Natalia Casado Fern{\'a}ndez and Roberto Pablo Meiss and Nils Tappenbeck and Yong Wang and Diego Raffo and Marina Simian and Anja Schwiebs and Roberto Gabriel Pozner and Juan I. Fuxman Bass and Andrea Gabriela Pozzi and Jorge Geffner and Edith Claudia Kordon and Carolina P. Schere-Levy},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2012},
  volume={26 5},
  pages={
          1982-94
        }
}
Angiotensin II (AngII), the main effector peptide of the renin-angiotensin system (RAS), participates in multiple biological processes, including cell growth, apoptosis, and tissue remodeling. Since AngII activates, in different cell types, signal transducing pathways that are critical for mammary gland postlactational regression, we investigated the role of the RAS during this process. We found that exogenous administration of AngII in mammary glands of lactating Balb/c mice induced epithelium… CONTINUE READING
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  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
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