AT1 receptor antagonist telmisartan administered peripherally inhibits central responses to angiotensin II in conscious rats.

@article{Gohlke2001AT1RA,
  title={AT1 receptor antagonist telmisartan administered peripherally inhibits central responses to angiotensin II in conscious rats.},
  author={Peter Gohlke and Samuel A Weiss and Angela Jansen and Wolfgang Wienen and Joachim Stangier and Wolfgang Rascher and Juraj Culman and Thomas Unger},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2001},
  volume={298 1},
  pages={62-70}
}
The effects of systemic treatment with the AT1 receptor antagonist telmisartan on central effects of angiotensin II (Ang II), namely, increase in blood pressure, vasopressin release into the circulation, and drinking response, were investigated in conscious, normotensive rats. The central responses to i.c.v. Ang II (30 ng/kg) were measured at 0.5, 2, 4, and 24 h following acute i.v. or acute and chronic oral telmisartan application. At a dose of 10 mg/kg i.v., the drinking response to i.c.v… CONTINUE READING
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