AT1 receptor antagonist Candesartan in selected cirrhotic patients: effect on portal pressure and liver fibrosis markers.

@article{DebernardiVenon2007AT1RA,
  title={AT1 receptor antagonist Candesartan in selected cirrhotic patients: effect on portal pressure and liver fibrosis markers.},
  author={Wilma Debernardi-Venon and Silvia Martini and Fiorella Biasi and Barbara Vizio and Angela Termine and Giuseppe Cozzoli Poli and Franco Brunello and Carlo Alessandria and Renato Bonardi and Giorgio Maria Saracco and Mario Rizzetto and Alfredo Marzano},
  journal={Journal of hepatology},
  year={2007},
  volume={46 6},
  pages={
          1026-33
        }
}
BACKGROUND/AIMS The renin-angiotensin system plays an important role in hepatic fibrogenesis and in portal hypertension. To examine the long-term effects of Candesartan cilexetil, an angiotensin type 1 (AT1) receptor blocker, on portal-systemic haemodynamics and on liver fibrosis. METHODS Forty-seven compensated Child A and Child B (8) cirrhotic patients were randomly assigned to receive Candesartan cilexetil, 8 mg/d (N.24) and no treatment (N.23) for 1 year. Portal-systemic haemodynamic… CONTINUE READING

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