AT1 receptor antagonism before ischemia prevents the transition of acute kidney injury to chronic kidney disease.

@article{RodrguezRomo2016AT1RA,
  title={AT1 receptor antagonism before ischemia prevents the transition of acute kidney injury to chronic kidney disease.},
  author={Roxana Rodr{\'i}guez-Romo and Kenia Zayas Ben{\'i}tez and Jonatan Barrera-Chimal and Rosalba P{\'e}rez-Villalva and Arturo G{\'o}mez and Diana Aguilar-Le{\'o}n and Jes{\'u}s F Rangel-Santiago and Sara Huerta and Gerardo Gamba and Norma Uribe Uribe and Norma A Bobadilla},
  journal={Kidney international},
  year={2016},
  volume={89 2},
  pages={
          363-73
        }
}
Despite clinical recovery of patients from an episode of acute kidney injury (AKI), progression to chronic kidney disease (CKD) is possible on long-term follow-up. However, mechanisms of this are poorly understood. Here, we determine whether activation of angiotensin-II type 1 receptors during AKI triggers maladaptive mechanisms that lead to CKD. Nine months after AKI, male Wistar rats develop CKD characterized by renal dysfunction, proteinuria, renal hypertrophy, glomerulosclerosis, tubular… CONTINUE READING

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