ASXL1 mutations in myeloid neoplasms: pathogenetic considerations, impact on clinical outcomes and survival.

BACKGROUND ASXL1 gene mutations include nonsense, missense, and frameshift mutations. Although their clinical significance is still debated, they may play an important role in the pathogenesis of several hematologic malignancies. METHODS Herein, we offer a comprehensive review on ASXL1 mutations, and link them with survival and clinical outcomes in… (More)