ASXL1 mutations are frequent and prognostically detrimental in CSF3R-mutated chronic neutrophilic leukemia.

@article{Elliott2015ASXL1MA,
  title={ASXL1 mutations are frequent and prognostically detrimental in CSF3R-mutated chronic neutrophilic leukemia.},
  author={Michelle A Elliott and Animesh Pardanani and Curtis A. Hanson and Terra L. Lasho and Christy M. Finke and Alem A. Belachew and Ayalew Tefferi},
  journal={American journal of hematology},
  year={2015},
  volume={90 7},
  pages={653-6}
}
Colony stimulating factor 3 receptor gene (CSF3R) mutations have recently been associated with chronic neutrophilic leukemia (CNL). Fourteen patients with CSF3R-mutated CNL (median age 67 years; 57% males) were screened for additional mutations; 8 (57%) and 5 (38%) harbored an ASXL1 and/or SETBP1 mutation (two patients expressed both), respectively. Two patients developed blastic transformation, both SETBP1-mutated and ASXL1-unmutated, whereas two other cases evolved into chronic myelomonocytic… CONTINUE READING
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CSF 3 R T 618 I is a highly prevalent and specific mutation in chronic neutrophilic leukemia

  • A Pardanani, TL Lasho, RR Laborde
  • 2013

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