ASP enhances in situ lipoprotein lipase activity by increasing fatty acid trapping in adipocytes.

@article{Faraj2004ASPEI,
  title={ASP enhances in situ lipoprotein lipase activity by increasing fatty acid trapping in adipocytes.},
  author={May Faraj and Allan David Sniderman and Katherine Cianflone},
  journal={Journal of lipid research},
  year={2004},
  volume={45 4},
  pages={657-66}
}
Acylation-stimulating protein (ASP) increases triglyceride (TG) storage (fatty acid trapping) in adipose tissue and plays an important role in postprandial TG clearance. We examined the capacity of ASP and insulin to stimulate the activity of lipoprotein lipase (LPL) and the trapping of LPL-derived nonesterified fatty acid (NEFA) in 3T3-L1 adipocytes. Although insulin increased total LPL activity (secreted and cell-associated; P < 0.001) in 3T3-L1 adipocytes, ASP moderately stimulated secreted… CONTINUE READING
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