ASK1-p38 MAPK-p47phox activation is essential for inflammatory responses during tuberculosis via TLR2-ROS signalling.

@article{Yang2008ASK1p38MA,
  title={ASK1-p38 MAPK-p47phox activation is essential for inflammatory responses during tuberculosis via TLR2-ROS signalling.},
  author={Chul-Su Yang and Dong-Min Shin and H J Lee and Ji Woong Son and Sung Joong Lee and Shizuo Akira and Marie-Anne Gougerot-Pocidalo and Jamel El-Benna and Hidenori Ichijo and Eun Kyeong Jo},
  journal={Cellular microbiology},
  year={2008},
  volume={10 3},
  pages={741-54}
}
The roles of intracellular reactive oxygen species (ROS) and related signalling pathways in mycobacterial infection are largely unknown. Here we show that tuberculin purified protein derivative (PPD)/Toll-like receptor (TLR) 2/ROS signalling through activation of apoptosis-regulating signal kinase (ASK) 1 and p47phox pathways is responsible for the induction of proinflammatory responses during tuberculosis (TB) infection. Tuberculin PPD stimulation resulted in rapid activation of mitogen… CONTINUE READING
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