ASK1 is essential for JNK/SAPK activation by TRAF2.


Tumor necrosis factor (TNF)-induced activation of the c-jun N-terminal kinase (JNK, also known as SAPK; stress-activated protein kinase) requires TNF receptor-associated factor 2 (TRAF2). The apoptosis signal-regulating kinase 1 (ASK1) is activated by TNF and stimulates JNK activation. Here we show that ASK1 interacts with members of the TRAF family and is… (More)


Cite this paper

@article{Nishitoh1998ASK1IE, title={ASK1 is essential for JNK/SAPK activation by TRAF2.}, author={Hideki Nishitoh and M. Saitoh and Yoshiyuki Mochida and K. Takeda and Hideki Nakano and Michael Thadd{\"a}us Rothe and Kazuhiro Miyazono and Hiroyuki Ichijo}, journal={Molecular cell}, year={1998}, volume={2 3}, pages={389-95} }