ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis.

@article{Iriyama2009ASK1AA,
  title={ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis.},
  author={Takayuki Iriyama and Kohsuke Takeda and Hiromi Nakamura and Yoshifumi Morimoto and Takumi Kuroiwa and Junya Mizukami and Tsuyoshi Umeda and Takuya Noguchi and Isao Naguro and Hideki Nishitoh and Kaoru Saegusa and Kei Tobiume and Toshiki Homma and Yutaka Shimada and Hitoshi Tsuda and Satoshi Aiko and Issei Imoto and Johji Inazawa and Kazuhiro Chida and Yoshimasa Kamei and Shiro Kozuma and Yuji Taketani and A. Matsuzawa and Hidenori Ichijo},
  journal={The EMBO journal},
  year={2009},
  volume={28 7},
  pages={843-53}
}
Apoptosis and inflammation generally exert opposite effects on tumorigenesis: apoptosis serves as a barrier to tumour initiation, whereas inflammation promotes tumorigenesis. Although both events are induced by various common stressors, relatively little is known about the stress-induced signalling pathways regulating these events in tumorigenesis. Here, we show that stress-activated MAP3Ks, ASK1 and ASK2, which are involved in cellular responses to various stressors such as reactive oxygen… CONTINUE READING

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