ASK1 (MAP3K5) as a potential therapeutic target in malignant fibrous histiocytomas with 12q14-q15 and 6q23 amplifications.

@article{Chibon2004ASK1A,
  title={ASK1 (MAP3K5) as a potential therapeutic target in malignant fibrous histiocytomas with 12q14-q15 and 6q23 amplifications.},
  author={Fr{\'e}d{\'e}ric Chibon and Odette Mariani and Josette Derr{\'e} and Aline Mairal and J. M. Coindre and Louis C. Guillou and Xavier Sastre and Florence Pedeutour and Alain Aurias},
  journal={Genes, chromosomes & cancer},
  year={2004},
  volume={40 1},
  pages={32-7}
}
Malignant fibrous histiocytomas (MFHs) are aggressive tumors without any definable line of differentiation. We recently demonstrated that about 20% of them are characterized by high-level amplifications of the 12q14-q15 chromosome region, associated with either 1p32 or 6q23 band amplification. This genetic finding, very similar to that in well-differentiated liposarcomas, strongly suggests that these tumors actually correspond to undifferentiated liposarcomas. It also suggests that the lack of… CONTINUE READING
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