ASIC2a and ASIC3 heteromultimerize to form pH-sensitive channels in mouse cardiac dorsal root ganglia neurons.

@article{Hattori2009ASIC2aAA,
  title={ASIC2a and ASIC3 heteromultimerize to form pH-sensitive channels in mouse cardiac dorsal root ganglia neurons.},
  author={Tomonori Hattori and Jie Chen and Anne Marie S. Harding and Margaret P. Price and Yongjun Lu and François M. Abboud and Christopher J. Benson},
  journal={Circulation research},
  year={2009},
  volume={105 3},
  pages={279-86}
}
RATIONALE Acid-sensing ion channels (ASICs) are Na+ channels that are activated by acidic pH. Their expression in cardiac afferents and remarkable sensitivity to small pH changes has made them leading candidates to sense cardiac ischemia. OBJECTIVE Four genes encode six different ASIC subunits, however it is not yet clear which of the ASIC subunits contribute to the composition of ASICs in cardiac afferents. METHODS AND RESULTS Here, we labeled cardiac afferents using a retrograde tracer… CONTINUE READING

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