ASIC and ENaC type sodium channels: conformational states and the structures of the ion selectivity filters

@article{Hanukoglu2017ASICAE,
  title={ASIC and ENaC type sodium channels: conformational states and the structures of the ion selectivity filters},
  author={Israel Hanukoglu},
  journal={The FEBS Journal},
  year={2017},
  volume={284}
}
The acid‐sensing ion channels (ASICs) and epithelial sodium channels (ENaC) are members of a superfamily of channels that play critical roles in mechanosensation, chemosensation, nociception, and regulation of blood volume and pressure. These channels look and function like a tripartite funnel that directs the flow of Na+ ions into the cytoplasm via the channel pore in the membrane. The subunits that form these channels share a common structure with two transmembrane segments (TM1 and TM2) and… Expand
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