ASH structure alignment package: Sensitivity and selectivity in domain classification

@article{Standley2007ASHSA,
  title={ASH structure alignment package: Sensitivity and selectivity in domain classification},
  author={Daron M. Standley and Hiroyuki Toh and Haruki Nakamura},
  journal={BMC Bioinformatics},
  year={2007},
  volume={8},
  pages={116 - 116}
}
Structure alignment methods offer the possibility of measuring distant evolutionary relationships between proteins that are not visible by sequence-based analysis. However, the question of how structural differences and similarities ought to be quantified in this regard remains open. In this study we construct a training set of sequence-unique CATH and SCOP domains, from which we develop a scoring function that can reliably identify domains with the same CATH topology and SCOP fold… CONTINUE READING
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