ASF/SF2-Regulated CaMKIIδ Alternative Splicing Temporally Reprograms Excitation-Contraction Coupling in Cardiac Muscle

@article{Xu2005ASFSF2RegulatedCA,
  title={ASF/SF2-Regulated CaMKIIδ Alternative Splicing Temporally Reprograms Excitation-Contraction Coupling in Cardiac Muscle},
  author={Xiangdong Xu and Dongmei Yang and Jian-hua Ding and Wang Wang and Pao-Hsien Chu and Nancy D. Dalton and Huan-You Wang and John R. Bermingham and Zhen Ye and Forrest Liu and Michael G. Rosenfeld and James L Manley and John Ross and Ju Chen and Rui-ping Xiao and Heping Cheng and Xiang-Dong Fu},
  journal={Cell},
  year={2005},
  volume={120},
  pages={59-72}
}
The transition from juvenile to adult life is accompanied by programmed remodeling in many tissues and organs, which is key for organisms to adapt to the demand of the environment. Here we report a novel regulated alternative splicing program that is crucial for postnatnal heart remodeling in the mouse. We identify the essential splicing factor ASF/SF2 as a key component of the program, regulating a restricted set of tissue-specific alternative splicing events during heart remodeling… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS