ASCL1 reprograms mouse Muller glia into neurogenic retinal progenitors.

  title={ASCL1 reprograms mouse Muller glia into neurogenic retinal progenitors.},
  author={Julia Pollak and Matthew S. Wilken and Yumi Ueki and Kristen E. Cox and Jane M. Sullivan and Russell J. Taylor and Edward M. Levine and Thomas A. Reh},
  volume={140 12},
Non-mammalian vertebrates have a robust ability to regenerate injured retinal neurons from Müller glia (MG) that activate the gene encoding the proneural factor Achaete-scute homolog 1 (Ascl1; also known as Mash1 in mammals) and de-differentiate into progenitor cells. By contrast, mammalian MG have a limited regenerative response and fail to upregulate Ascl1 after injury. To test whether ASCL1 could restore neurogenic potential to mammalian MG, we overexpressed ASCL1 in dissociated mouse MG… CONTINUE READING
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