ASCIZ regulates lesion-specific Rad51 focus formation and apoptosis after methylating DNA damage.

@article{McNees2005ASCIZRL,
  title={ASCIZ regulates lesion-specific Rad51 focus formation and apoptosis after methylating DNA damage.},
  author={Carolyn J. McNees and Lindus A. Conlan and Nora Tenis and J{\"o}rg Heierhorst},
  journal={The EMBO journal},
  year={2005},
  volume={24 13},
  pages={2447-57}
}
Nuclear Rad51 focus formation is required for homology-directed repair of DNA double-strand breaks (DSBs), but its regulation in response to non-DSB lesions is poorly understood. Here we report a novel human SQ/TQ cluster domain-containing protein termed ASCIZ that forms Rad51-containing foci in response to base-modifying DNA methylating agents but not in response to DSB-inducing agents. ASCIZ foci seem to form prior to Rad51 recruitment, and an ASCIZ core domain can concentrate Rad51 in focus… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 47 references

Similar Papers

Loading similar papers…