ASC spheroid geometry and culture oxygenation differentially impact induction of preangiogenic behaviors in endothelial cells.

@article{Skiles2015ASCSG,
  title={ASC spheroid geometry and culture oxygenation differentially impact induction of preangiogenic behaviors in endothelial cells.},
  author={Matthew Lorincz Skiles and Brandon William Hanna and Lindsay Rucker and Allison Breanne Tipton and Aidan Brougham-Cook and Ehsan Jabbarzadeh and James Otto Blanchette},
  journal={Cell transplantation},
  year={2015},
  volume={24 11},
  pages={
          2323-35
        }
}
Cell-based angiogenic therapies offer potential for the repair of ischemic injuries, while avoiding several of the limitations associated with material-based growth factor delivery strategies. Evidence supports that applying MSCs as spheroids rather than dispersed cells can improve retention and enhance therapeutic effect through increased secretion of angiogenic factors due to hypoxia. However, while spheroid culture appears to modulate MSC behavior, there has been little investigation of how… CONTINUE READING
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