ASC amino acid transporter 2, defined by enzyme‐mediated activation of radical sources, enhances malignancy of GD2‐positive small‐cell lung cancer

@inproceedings{Esaki2018ASCA,
  title={
ASC amino acid transporter 2, defined by enzyme‐mediated activation of radical sources, enhances malignancy of GD2‐positive small‐cell lung cancer},
  author={Nobutoshi Esaki and Yuki Ohkawa and Noboru Hashimoto and Yuhsuke Tsuda and Yuhsuke Ohmi and Robiul Hasan Bhuiyan and Norihiro Kotani and Koichi Honke and Atsushi Enomoto and Masahide Takahashi and Koichi Furukawa},
  booktitle={Cancer science},
  year={2018}
}
Ganglioside GD2 is specifically expressed in small-cell lung cancer (SCLC) cells, leading to enhancement of malignant phenotypes, such as cell proliferation and migration. However, how GD2 promotes malignant phenotypes in SCLC cells is not well known. In this study, to reveal the mechanisms by which GD2 increases malignant phenotypes in SCLC cells, we used enzyme-mediated activation of radical sources combined with mass spectrometry in GD2+ SCLC cells. Consequently, we identified ASC amino acid… CONTINUE READING
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