ASC Methylation and Interleukin-1β Are Associated with Aerobic Capacity in Heart Failure.

@article{Butts2017ASCMA,
  title={ASC Methylation and Interleukin-1β Are Associated with Aerobic Capacity in Heart Failure.},
  author={Brittany Butts and Javed Butler and Sandra B. Dunbar and Elizabeth J. Corwin and Rebecca Ann Gary},
  journal={Medicine and science in sports and exercise},
  year={2017},
  volume={49 6},
  pages={
          1072-1078
        }
}
BACKGROUND Aerobic capacity, as measured by peak oxygen uptake (V˙O2), is one of the most powerful predictors of prognosis in heart failure (HF). Inflammation is a key factor contributing to alterations in aerobic capacity, and interleukin (IL)-1 cytokines are implicated in this process. The adaptor protein ASC is necessary for inflammasome activation of IL-1β and IL-18. ASC expression is controlled through epigenetic modification; lower ASC methylation is associated with worse outcomes in HF… CONTINUE READING

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