ASC-J9 suppresses castration-resistant prostate cancer growth through degradation of full-length and splice variant androgen receptors.

@article{Yamashita2012ASCJ9SC,
  title={ASC-J9 suppresses castration-resistant prostate cancer growth through degradation of full-length and splice variant androgen receptors.},
  author={Shinichi Yamashita and Kuo-Pao Lai and K L Chuang and Defeng Xu and Hiroshi Miyamoto and Tatsuo Tochigi and See-Tong Pang and Lei Erbao Li and Yoichi Arai and Hsing-Jien Kung and Shuyuan Yeh and Chawnshang Chang},
  journal={Neoplasia},
  year={2012},
  volume={14 1},
  pages={74-83}
}
Early studies suggested androgen receptor (AR) splice variants might contribute to the progression of prostate cancer (PCa) into castration resistance. However, the therapeutic strategy to target these AR splice variants still remains unresolved. Through tissue survey of tumors from the same patients before and after castration resistance, we found that the expression of AR3, a major AR splice variant that lacks the AR ligand-binding domain, was substantially increased after castration… CONTINUE READING

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