ASB2 is an Elongin BC-interacting protein that can assemble with Cullin 5 and Rbx1 to reconstitute an E3 ubiquitin ligase complex.

@article{Heuz2005ASB2IA,
  title={ASB2 is an Elongin BC-interacting protein that can assemble with Cullin 5 and Rbx1 to reconstitute an E3 ubiquitin ligase complex.},
  author={M{\'e}lina L. Heuz{\'e} and Florence C. Guibal and Charles A. S. Banks and Joan W Conaway and Ronald C. Conaway and Yvon E. Cayre and Arndt G. Benecke and Pierre G. Lutz},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 7},
  pages={5468-74}
}
The ankyrin repeat-containing protein with a suppressor of cytokine signaling box-2 (ASB2) gene was identified as a retinoic acid-response gene and a target of the promyelocytic leukemia-retinoic acid receptor-alpha oncogenic protein characteristic of acute promyelocytic leukemia. Expression of ASB2 in myeloid leukemia cells inhibits growth and promotes commitment, recapitulating an early step known to be critical for differentiation. Here we show that ASB2, by interacting with the Elongin BC… CONTINUE READING
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