AS601245, an Anti-Inflammatory JNK Inhibitor, and Clofibrate Have a Synergistic Effect in Inducing Cell Responses and in Affecting the Gene Expression Profile in CaCo-2 Colon Cancer Cells

@inproceedings{Cerbone2012AS601245AA,
  title={AS601245, an Anti-Inflammatory JNK Inhibitor, and Clofibrate Have a Synergistic Effect in Inducing Cell Responses and in Affecting the Gene Expression Profile in CaCo-2 Colon Cancer Cells},
  author={Angelo Cerbone and Cristina Toaldo and Stefania Pizzimenti and Piergiorgio Pettazzoni and Chiara Dianzani and Rosalba Minelli and Eric Ciamporcero and Guglielmo Roma and Mario Umberto Dianzani and Roberto Canaparo and Carlo G. Ferretti and Giuseppina Barrera},
  booktitle={PPAR research},
  year={2012}
}
PPARαs are nuclear receptors highly expressed in colon cells. They can be activated by the fibrates (clofibrate, ciprofibrate etc.) used to treat hyperlipidemia. Since PPARα transcriptional activity can be negatively regulated by JNK, the inhibition of JNK activity could increase the effectiveness of PPARα ligands. We analysed the effects of AS601245 (a JNK inhibitor) and clofibrate alone or in association, on proliferation, apoptosis, differentiation and the gene expression profile of CaCo-2… CONTINUE READING
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