AS3MT, GSTO, and PNP polymorphisms: impact on arsenic methylation and implications for disease susceptibility.

@article{Antonelli2014AS3MTGA,
  title={AS3MT, GSTO, and PNP polymorphisms: impact on arsenic methylation and implications for disease susceptibility.},
  author={Ray Antonelli and Kan Shao and David J Thomas and Reeder L. Sams and John D. Cowden},
  journal={Environmental research},
  year={2014},
  volume={132},
  pages={
          156-67
        }
}
BACKGROUND Oral exposure to inorganic arsenic (iAs) is associated with adverse health effects. Epidemiological studies suggest differences in susceptibility to these health effects, possibly due to genotypic variation. Genetic polymorphisms in iAs metabolism could lead to increased susceptibility by altering urinary iAs metabolite concentrations. OBJECTIVE To examine the impact of genotypic polymorphisms on iAs metabolism. METHODS We screened 360 publications from PubMed and Web of Science… CONTINUE READING

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