AS1411 aptamer tagged PLGA‐lecithin‐PEG nanoparticles for tumor cell targeting and drug delivery

  title={AS1411 aptamer tagged PLGA‐lecithin‐PEG nanoparticles for tumor cell targeting and drug delivery},
  author={A. Aravind and Prashanti Jeyamohan and Remya Nair and S. Veeranarayanan and Y. Nagaoka and Yasuhiko Yoshida and T. Maekawa and D. S. Kumar},
  journal={Biotechnology and Bioengineering},
  • A. Aravind, Prashanti Jeyamohan, +5 authors D. S. Kumar
  • Published 2012
  • Chemistry, Medicine
  • Biotechnology and Bioengineering
  • Liposomes and polymers are widely used drug carriers for controlled release since they offer many advantages like increased treatment effectiveness, reduced toxicity and are of biodegradable nature. In this work, anticancer drug‐loaded PLGA‐lecithin‐PEG nanoparticles (NPs) were synthesized and were functionalized with AS1411 anti‐nucleolin aptamers for site‐specific targeting against tumor cells which over expresses nucleolin receptors. The particles were characterized by transmission electron… CONTINUE READING
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