ARTS and Siah collaborate in a pathway for XIAP degradation.

  title={ARTS and Siah collaborate in a pathway for XIAP degradation.},
  author={Jason B Garrison and Ricardo G Correa and Motti Gerlic and Kenneth W. Yip and Andreas Krieg and Craig M Tamble and Ranxin Shi and Kate Welsh and Srinivas Duggineni and Ziwei Huang and Keqin Ren and Chunying Du and John C. Reed},
  journal={Molecular cell},
  volume={41 1},
ARTS (apoptosis-related protein in the TGF-β signaling pathway) is a mitochondrial protein that binds XIAP (X-linked inhibitor of apoptosis protein) upon entering the cytosol, thus promoting cell death. Expression of ARTS is lost in some malignancies. Here, we show that ARTS binds to XIAP at BIR1, a domain distinct from the caspase-binding sites. Furthermore, ARTS interacts with the E3 ligase Siah-1 (seven in absentia homolog 1) to induce ubiquitination and degradation of XIAP. Cells lacking… CONTINUE READING
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