ARTEMIS stabilizes the genome and modulates proliferative responses in multipotent mesenchymal cells

@inproceedings{Maas2010ARTEMISST,
  title={ARTEMIS stabilizes the genome and modulates proliferative responses in multipotent mesenchymal cells},
  author={Sarah A Maas and Nina M. Donghia and Kathleen Tompkins and Oded Foreman and Kevin D. Mills},
  booktitle={BMC Biology},
  year={2010}
}
Unrepaired DNA double-stranded breaks (DSBs) cause chromosomal rearrangements, loss of genetic information, neoplastic transformation or cell death. The nonhomologous end joining (NHEJ) pathway, catalyzing sequence-independent direct rejoining of DSBs, is a crucial mechanism for repairing both stochastically occurring and developmentally programmed DSBs. In lymphocytes, NHEJ is critical for both development and genome stability. NHEJ defects lead to severe combined immunodeficiency (SCID) and… CONTINUE READING