ART2, a T cell surface mono-ADP-ribosyltransferase, generates extracellular poly(ADP-ribose).

@article{Morrison2006ART2AT,
  title={ART2, a T cell surface mono-ADP-ribosyltransferase, generates extracellular poly(ADP-ribose).},
  author={Alan R Morrison and Joel Moss and Linda A. Stevens and James E. Evans and Caitlin A. Farrell and Eric Lee Merithew and David G. Lambright and Dale L. Greiner and John P Mordes and Aldo A. Rossini and Rita Bortell},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 44},
  pages={
          33363-72
        }
}
NAD functions in multiple aspects of cellular metabolism and signaling through enzymes that covalently transfer ADP-ribose from NAD to acceptor proteins, thereby altering their function. NAD is a substrate for two enzyme families, mono-ADP-ribosyltransferases (mARTs) and poly(ADP-ribose) polymerases (PARPs), that covalently transfer an ADP-ribose monomer or polymer, respectively, to acceptor proteins. ART2, a mART, is a phenotypic marker of immunoregulatory cells found on the surface of T… CONTINUE READING

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