ARRB1-mediated regulation of E2F target genes in nicotine-induced growth of lung tumors.

  title={ARRB1-mediated regulation of E2F target genes in nicotine-induced growth of lung tumors.},
  author={Piyali Dasgupta and Wasia Rizwani and Smitha R Pillai and Rebecca Marie Davis and Sarmistha Banerjee and Kevin T. Hug and Mark Lloyd and Domenico Coppola and Eric B. Haura and Srikumar Chellappan},
  journal={Journal of the National Cancer Institute},
  volume={103 4},
BACKGROUND Nicotine induces the proliferation of non-small cell lung cancer (NSCLC) cells via nicotinic acetylcholine receptors and the arrestin, β1 (ARRB1) protein. However, whether ARRB1 translocates to the nucleus upon nicotinic acetylcholine receptor activation and how it regulates growth of human NSCLCs are not known. METHODS We investigated nuclear localization of ARRB1 in human NSCLC cell lines (A549 and H1650), normal lung cell lines (NHBE and SAEC), and lung cancer tissue microarray… CONTINUE READING
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