ARNO but not cytohesin-1 translocation is phosphatidylinositol 3-kinase-dependent in HL-60 cells.

@article{Bourgoin2002ARNOBN,
  title={ARNO but not cytohesin-1 translocation is phosphatidylinositol 3-kinase-dependent in HL-60 cells.},
  author={Sylvain G. Bourgoin and Martin G Houle and Indrapal N. Singh and Danielle Harbour and Steve N. Gagnon and Andrew J. Morris and David N. Brindley},
  journal={Journal of leukocyte biology},
  year={2002},
  volume={71 4},
  pages={718-28}
}
Cytohesin-1 and ARNO are guanine nucleotide-exchange factors (GEFs) for ADP-ribosylation factor (Arf). Here, we show that ARNO is expressed in HL-60 cells and established that granulocytic differentiation induced with Me2SO stimulated cytohesin-1 but not ARNO expression. Cytohesin-1 levels in HL-60 granulocytes were similar to those in human neutrophils. Me2SO-differentiated HL-60 cells expressed ARNO and cytohesin-1 isoforms with a diglycine and a triglycine motif in their PH domains… CONTINUE READING
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