ARID5B gene rs10821936 polymorphism is associated with childhood acute lymphoblastic leukemia: a meta-analysis based on 39,116 subjects

  title={ARID5B gene rs10821936 polymorphism is associated with childhood acute lymphoblastic leukemia: a meta-analysis based on 39,116 subjects},
  author={Lei-ming Guo and Jia-shui Xi and Yan Ma and Lin Shao and C L Nie and Guang-Jun Wang},
  journal={Tumor Biology},
Childhood acute lymphoblastic leukemia (ALL) is the leading cause of cancer-related deaths among children. Two recent genome-wide association studies and several replicated studies have provided convincing evidence that inherited genetic variation in ARID5B contributes to childhood ALL predisposition. In the present study, we performed a meta-analysis to systematically summarize the association between ARID5B genetic polymorphism and the risk for ALL. We conducted a search of case–control… 

Associations between AT-rich interactive domain 5B gene polymorphisms and risk of childhood acute lymphoblastic leukemia: a meta-analysis.

Subtype analyses of B-lineage ALL provided strong evidence that SNP rs10994982 is highly associated with the risk of developing B-hyperdiploid ALL, and meta-analysis indicated that SNPs rs10 994982 and rs7089424 are indeed significantly associated with increased risk of childhood ALL.

IKZF1 gene polymorphisms increased the risk of childhood acute lymphoblastic leukemia in an Iranian population

The study aimed to inspect the impact of IKZF1 gene polymorphisms and childhood ALL in a sample of Iranian population who live in south east of Iran and revealed that the rs10272724 T > C polymorphism increased the risk of ALL in codominant and dominant inheritance models.

Association between ARID5B Polymorphisms and the Risk for Childhood B- Acute Lymphoblastic Leukaemia

A meta-analysis demonstrated that six candidate ARID5B polymorphisms could serve as promising markers for assessing the susceptibility risk to childhood B-ALL in both the Asian and Caucasian populations.

Association of the independent polymorphisms in CDKN2A with susceptibility of acute lymphoblastic leukemia

It is indicated that two SNPs at CDKN2A locus are associated with ALL susceptibility independently mainly in Caucasians, and future large-scale studies are required to validate the associations in other ethnicities.

Analysis of possible genetic risk factors contributing to development of childhood acute lymphoblastic leukaemia in the Latvian population

The identified SNP rs10821936 in the ARID5B gene could serve as a potential risk marker for childhood ALL development and is identified as the strongest association being found in a combination where all five genetic variants are in a homozygous state.

Association Between PIP4K2A Polymorphisms and Acute Lymphoblastic Leukemia Susceptibility

A meta-analysis systematically investigated the relationship between SNPs at PIP4K2A locus and ALL susceptibility, and further found potential causal variant candidates, thus better elucidating the role of PIP2A gene in leukemogenesis.

High Resolution Melting Analysis for Evaluation of mir-612 (Rs12803915) Genetic Variant with Susceptibility to Pediatric Acute Lymphoblastic Leukemia.

HRM is a suitable method to detect SNP rs12803915 in the mir-612 gene; however, it is found there is no significant association between the rs12 803915 polymorphism and ALL risk.

Association of ARID5B Genetic Variants with Risk of Childhood B Cell Precursor Acute Lymphoblastic Leukaemia in Latvia

Results of the study replicate and extend previously published findings for ARID5B localized allelic variants, but do not explain the mechanism of action related to the pathogenesis of ALL.

Association of MDR1 G2677T polymorphism and leukemia risk: evidence from a meta-analysis

The results suggested that there was no association between MDR1 G2677T polymorphism and leukemia risk in overall populations, but significant association was found in others populations (Asians and Africans), and myeloid leukemia indicated that G26 77T polymorphisms might be a protective factor in the susceptibility of myeloids leukemia and in Asians and Africans.



ARID5B genetic polymorphisms contribute to racial disparities in the incidence and treatment outcome of childhood acute lymphoblastic leukemia.

  • Heng XuCheng Cheng Jun J. Yang
  • Medicine, Biology
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2012
ARID5B polymorphisms are important determinants of childhood ALL susceptibility and treatment outcome, and they contribute to racial disparities in this disease.

Candidate gene association study in pediatric acute lymphoblastic leukemia evaluated by Bayesian network based Bayesian multilevel analysis of relevance

Evaluating the survival rate of the patients with ALL, the BN-BMLA showed that besides risk groups and subtypes, genetic variations in the BAX and CEBPA genes might also influence the probability of survival of the Patients.

Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations.

Findings indicate strong associations between inherited genetic variation and ALL susceptibility in children and shed new light on ALL molecular etiology in diverse ancestry.

Genetic variants in ARID5B and CEBPE are childhood ALL susceptibility loci in Hispanics

Although IKZF1 loci showed significant susceptibility effects among NHWs, their effects among Hispanics were in the same direction but nonsignificant, despite similar minor allele frequencies, and future studies should examine whether the observed effects vary by environmental, immunological, or lifestyle factors.

Replication analysis confirms the association of ARID5B with childhood B-cell acute lymphoblastic leukemia

This study provides a strong rationale for more detailed analysis to identify the causal variants at this locus and to better understand the overall functional contribution of ARID5B to childhood acute lymphoblastic leukemia susceptibility.

Genetic polymorphisms in ARID5B, CEBPE, IKZF1 and CDKN2A in relation with risk of acute lymphoblastic leukaemia in adults: a Group for Research on Adult Acute Lymphoblastic Leukaemia (GRAALL) study

A total of 150 adult patients with newly diagnosed ALL were included in this study and enrolled on clinical trials on GRA, which validated whether these low-penetrance susceptibility alleles contribute to the risk of developing ALL in adults.

Genetic susceptibility to cancer: the role of polymorphisms in candidate genes.

In this review of candidate gene association studies, nearly one-third of gene-variant cancer associations were statistically significant, with variants in genes encoding for metabolizing enzymes among the most consistent and highly significant associations.