ARID4A and ARID4B regulate male fertility, a functional link to the AR and RB pathways.

  title={ARID4A and ARID4B regulate male fertility, a functional link to the AR and RB pathways.},
  author={R Wu and Ming Jiang and Arthur L Beaudet and Mei-Yi Wu},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={110 12},
ARID4A and ARID4B are homologous members of the ARID (AT-rich interaction domain) gene family. ARID4A and ARID4B physically interact with each other. ARID4A is a retinoblastoma (RB)-binding protein. Biological function of these interactions is still unknown. Here, we report that mice with complete deficiency of Arid4a, combined with haploinsufficiency of Arid4b (Arid4a(-/-)Arid4b(+/-)), showed progressive loss of male fertility, accompanied by hypogonadism and seminal vesicle agenesis… CONTINUE READING
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