ARID1A regulates R-loop associated DNA replication stress

  title={ARID1A regulates R-loop associated DNA replication stress},
  author={Shuhe Tsai and Emily Yun-chia Chang and Louis-Alexandre Fournier and James P. Wells and Sean W. Minaker and Yi Dan Zhu and Alan Ying-Hsu Wang and Yemin Wang and David G. Huntsman and Peter C. Stirling},
  journal={PLoS Genetics},
ARID1A is lost in up to 7% of all cancers, and this frequency increases in certain cancer types, such as clear cell ovarian carcinoma where ARID1A protein is lost in about 50% of cases. While the impact of ARID1A loss on the function of the BAF chromatin remodeller complexes is likely to drive oncogenic gene expression programs in specific contexts, ARID1A also binds genome stability regulators such as ATR and TOP2. Here we show that ARID1A loss leads to DNA replication stress associated with R… 
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