ARID1A loss is prevalent in endometrial hyperplasia with atypia and low-grade endometrioid carcinomas

@article{Werner2013ARID1ALI,
  title={ARID1A loss is prevalent in endometrial hyperplasia with atypia and low-grade endometrioid carcinomas},
  author={Henrica Maria Johanna Werner and Anna Berg and Elisabeth Wik and Even Birkeland and Camilla Krakstad and Kanthida Kusonmano and Kjell Petersen and Karl Henning Kalland and Anne Margrete Oyan and Lars Andreas Akslen and Jone Trovik and Helga Birgitte Salvesen},
  journal={Modern Pathology},
  year={2013},
  volume={26},
  pages={428-434}
}
ARID1A (AT-rich interactive domain 1A) has recently been identified as a tumor suppressor gene in various, predominantly gynecological cancers. We wanted to investigate the distribution of ARID1A in endometrial hyperplasia, carcinomas and metastatic lesions to elucidate the timing of expression loss of its protein ARID1A in the course of endometrial cancer carcinogenesis. In addition, we wanted to assess the relationship between the loss of ARID1A and clinicopathological variables in… CONTINUE READING
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