ARHGAP18: an endogenous inhibitor of angiogenesis, limiting tip formation and stabilizing junctions.

Abstract

The formation of the vascular network requires a tightly controlled balance of pro-angiogenic and stabilizing signals. Perturbation of this balance can result in dysregulated blood vessel morphogenesis and drive pathologies including cancer. Here, we have identified a novel gene, ARHGAP18, as an endogenous negative regulator of angiogenesis, limiting pro… (More)
DOI: 10.4161/21541248.2014.975002

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