ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation.

@article{Zilberman2003ARGONAUTE4CO,
  title={ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation.},
  author={Daniel Zilberman and Xiaofeng Cao and Steven E. Jacobsen},
  journal={Science},
  year={2003},
  volume={299 5607},
  pages={716-9}
}
Proteins of the ARGONAUTE family are important in diverse posttranscriptional RNA-mediated gene-silencing systems as well as in transcriptional gene silencing in Drosophila and fission yeast and in programmed DNA elimination in Tetrahymena. We cloned ARGONAUTE4 (AGO4) from a screen for mutants that suppress silencing of the Arabidopsis SUPERMAN (SUP) gene. The ago4-1 mutant reactivated silent SUP alleles and decreased CpNpG and asymmetric DNA methylation as well as histone H3 lysine-9… CONTINUE READING
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