ARFGAP1 Is Dynamically Associated with Lipid Droplets in Hepatocytes

  title={ARFGAP1 Is Dynamically Associated with Lipid Droplets in Hepatocytes},
  author={Joan Gannon and J. J. Fernandez-Rodriguez and Hussam Alamri and Shi Bo Feng and Fariba Kalantari and Sarita Negi and Amy H. Y. Wong and Alexander Mazur and Lennart Asp and Ali R. Fazel and Ayat Salman and Anthoula Lazaris and Peter P Metrakos and John J. M. Bergeron and Tommy Nilsson},
  booktitle={PloS one},
The ARF GTPase Activating Protein 1 (ARFGAP1) associates mainly with the cytosolic side of Golgi cisternal membranes where it participates in the formation of both COPI and clathrin-coated vesicles. In this study, we show that ARFGAP1 associates transiently with lipid droplets upon addition of oleate in cultured cells. Also, that addition of cyclic AMP shifts ARFGAP1 from lipid droplets to the Golgi apparatus and that overexpression and knockdown of ARFGAP1 affect lipid droplet formation… CONTINUE READING
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ARFGAP1 promotes AP-2-dependent endocytosis

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