ARF6-regulated endocytosis of growth factor receptors links cadherin-based adhesion to canonical Wnt signaling in epithelia.

@article{PellnCrdenas2013ARF6regulatedEO,
  title={ARF6-regulated endocytosis of growth factor receptors links cadherin-based adhesion to canonical Wnt signaling in epithelia.},
  author={Oscar Pell{\'o}n-C{\'a}rdenas and James T Clancy and Henriette Uwimpuhwe and Crislyn D'Souza-Schorey},
  journal={Molecular and cellular biology},
  year={2013},
  volume={33 15},
  pages={2963-75}
}
Wnt signaling has an essential role in embryonic development as well as stem/progenitor cell renewal, and its aberrant activation is implicated in many diseases, including several cancers. β-Catenin is a critical component of Wnt-mediated transcriptional activation. Here we show that ARF6 activation during canonical Wnt signaling promotes the intracellular accumulation of β-catenin via a mechanism that involves the endocytosis of growth factor receptors and robust activation of extracellular… CONTINUE READING
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